Ribociclib plus fulvestrant for advanced breast cancer: Health-related quality-of-life analyses from the MONALEESA-3 study

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Key Takeaway: Ribociclib plus fulvestrant maintained Health-Related Quality of Life (HRQOL) while improving progression-free survival compared to placebo. Hazard Ratios for deterioration favored Ribociclib but were not statistically significant.

Study Design & Arms

Baseline Quality of Life & Pain Scores

Comparison of baseline scores (Mean ± SD) between arms. Higher QOL is better; Lower Pain is better.

Hazard Ratios for Deterioration

Time to Definitive Deterioration (TTD) ≥10%. HR < 1 favors Ribociclib. Error bars represent 95% CI.

Global Health Status (QOL) Detail

Baseline scores were comparable. The Hazard Ratio (0.81) suggests a trend towards delayed deterioration with Ribociclib.

Pain Score Detail

Baseline pain was low in both groups. HR (0.77) for pain deterioration favored Ribociclib.

Effect Direction Summary

Summary of whether the intervention favored Ribociclib (Left) or Placebo (Right) based on Hazard Ratios.

Appendix: Raw Data & Sources

Extracted Metrics

ID Metric Group Value Source

Study Limits

    Selected: none

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