Ribociclib plus fulvestrant for advanced breast cancer: Health-related quality-of-life analyses from the MONALEESA-3 study

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0.81
HR for Global Health Deterioration
20.4 mo
Median Follow-up
Maintained
Overall HRQOL Status

Study Design & Methods

Randomized comparison of Ribociclib + Fulvestrant vs Placebo + Fulvestrant in HR+/HER2- advanced breast cancer.

Baseline EORTC QLQ-C30 Scores

Comparison of mean baseline scores across groups. Higher Global Health is better; Lower Fatigue/Pain is better.

Time to Deterioration (Hazard Ratios)

Hazard Ratios < 1.0 favor Ribociclib. Error bars represent 95% CI.

Baseline Symptom Burden

Comparison of Fatigue vs Pain scores at baseline. Lower scores indicate less symptom burden.

Risk Reduction Magnitude

Percentage reduction in risk of deterioration (1 - HR) for Ribociclib vs Placebo.

Study Population (2:1 Randomization)

Distribution of patients across treatment arms.

Appendix: Raw Data & Provenance

Metric Group/Comparison Value Source
Selected: none

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